The evaluation of new bone in extraction sockets healing with Emdogain and Bio-Oss collagen

The purpose of this study was to evaluate the healing and the formation of new bone in extraction sockets filled with Emdogain® and Bio-Oss® Collagen and covered by using the punch graft technique. Ten (5 male and 5 female) patients having symmetrical teeth in contralateral quadrants of the same jaw condemned for extraction were participated in our study. After the initial periodontal therapy, the surgical operations were started. In the first operation, following tooth extraction, one site was received Emdogain® while the other socket was filled with Bio-Oss® Collagen. Primary coverage of the socket was achieved by using a mucosal punch graft harvested from the palate. After 3 months of healing period, in the second operation, the augmented extraction sites were re-entered. Bone biopsies (2X8 mm) were obtained and the histological examinations were started. Dental implants were placed. The numeric stability values of implants were evaluated by resonance frequency analysis (RFA). Implant stability measurements were re-evaluated at first and third months. Histologic examination revealed new bone in all specimens. When we compare the new bone between Emdogain® and Bio-Oss® Collagen groups, there was no statistically significant differences respectively in apical and coronal sections of biopsies between two groups. RFA values were statistically higher for implants placed in Emdogain® sites at first and third months while no significant differences were seen in RFA values for implants placed in Bio-Oss® Collagen sites. There was no correlation between the amount of new bone in sockets and baseline RFA values for implants in Emdogain® and Bio-Oss® Collagen groups.