Minyatür ve vücuda yerleştirilebilir bir kalp pompasının sol karıncık destek sistemi olarak geliştirilmesi: Santrifüj Türk kalbi

Heart disease is one of the most common, unexpected and number one cause of death globally; according to world health organization, approximately 17.5 million people died because of cardiovascular heart disease in 2005 which represents the 30 % of all of the deaths worldwide. In Turkey, similar situation also occurs; 55% of the total deaths is because of the heart failure problems. According to the Europe Heart Health Research, Turkey is the European leader in the number of heart failures for the ages of less than 50. In Turkey, every year approximately 500,000 patients have heart failure and 2000 to 3000 of them need urgent heart transplantation. Unfortunately, due to lack of donors, only about a few operations can be done every year.During the long waiting time for a healthy donor heart, an artificial heart, mainly a ventricular assist device is currently the only hope and possible solution for the patients. Artificial heart pumps are known to be the best solutions for bridge-to-transplant, bridge-to-recovery and final medical solution for the patients who suffer from heart failures that result from the overfilling of the blood vessels of heart.There are various ventricular assist devices produced in the developed countries. It is imported and used in about 20 patients in Turkey. Costs of LVAD systems are very high and not affordable by many patients in Turkey. The aim of this thesis is to develop a new ventricular assist device in Turkey. The VAD system being developed is named as ?Heart Turcica?. The development process of the Heart Turcica LVAD system of five main parts: CAD (Computer Aided Design), CFD (Computational Fluid Dynamics) analyses, CAM (Computer Aided Manufacturing), precision production by Computer Numerical Control (CNC) machines and performance testing. The developed Heart Turcica LVAD system consists of a centrifugal pump, control unit and peripheral equipments. The pressure rise of the heart pump, flow rates and rotational speeds are controlled and monitored in the experiments.Heart Turcica Centrifugal is designed and manufactured from Titanium alloy to be biocompatible with the blood tests in the hospital. In this thesis, the design process of the heart pump, the performance curves of several designs, and the results of in-vitro experiments carried out are presented.