Neurogulin 1 genindeki bazı polimorfizmlerin şizofreni ile ilişkisi üzerine bir araştırma

Schizophrenia is a multifactorial disorder. Many characteristic single nucleotide polymorphisms (SNPs), accompanying their narrow impact, collectively can describe around 30% of the essential risk of schizophrenia. Finding susceptibility genes that play role in development of schizophrenia can explain the risk factors of the disease. Neuregulin 1 or NRG1 is crucial for the ordinary development of the nervous system. NRG1 was initially involved in schizophrenia in the Icelandic community after linkage disequilibrium aligning over 8p21–22 displayed association between schizophrenia. We investigated two NRG1 SNPs (rs3924999 and rs2954041) to find association with schizophrenia. We included 178 patients with schizophrenia and 180 healthy individuals as controls from a Turkish population living in Malatya. SNP genotyping was carried out with PCR-RFLP (polymerase chain reaction-restriction fragment length polymorphism) method and case and control groups were compared for a potential difference between distributions of genotypes and alleles. The case-control study we have done showed there was no significant difference in terms of genotype and allelic distributions of rs3924999 and rs2954041 SNPs between case and control groups we have screened. We were not able to find enough evidence to support presence of a single SNP association between schizophrenia and two SNPs concerned in this study.