Synthesis of new benzimidazole derivatives including nifuroxazide analoges and investigation of antimicrobial effects

In this work, it is aimed to synthesize new benzimidazole derivatives including nifuroxazide analoges, to confirm the structures by spectroscopic analyses, to observe antimicrobial and cytotoxic effects. Today, although there are a lot of drugs being used for microbial infections, much of the research still has been continued in this area on account of the unsatisfactory status of present treatment of microorganisms, drug side effects, toxic effects and the acquisition by the infecting organisms of the resistance to the present drugs. In the present study designed benzimidazole compounds will be synthesized by the microwave supported reactions. Structures of these compounds were elucidated by IR, 1H-NMR, 13C-NMR and Mass spectroscopic data and Elementary analyses results. Antimicrobial and cytotoxic effects of the synthesized compounds were determined by in-vitro activity tests. The compound C44 containing 6-flourobenzimidazole, hidrazone and 2-methylphenyl moiety in its structure exhibitied the highest activity against Escherichia coli O157:H7 and Escherichia coli ATCC 8739 with a MIC90 value of ≤1.95 µg/mL. According to cytotoxicity results of the same compound, it is observed that IC50 values is 107.81 times higher than MIC90 value.