A novel hybrid scaffold for managing critical size mandibular defects

This study provides a comprehensive approach to managing segmental mandibular defects. The patient's computed tomography images were used to design a patient-specific reconstruction plate. The mandible was reconstructed using virtual surgery, and new reference parameters were developed using craniometric and anatomical structures. Topology optimization and light-weighting were performed using the Voronoi and hollow patterns based on the areas with the most and least forces. The Voronoi pattern was used for the first time in topology optimization of a reconstruction plate. Structural analyses were conducted on the final designs. The Voronoi pattern is advantageous for clinical use, providing stability while using less material. The hollow design is effective, offering strength, screening for cancer recurrence, and easy removal after healing. A bioprinted bone scaffold was designed to improve function, healing, and aesthetics. An 0/90 hybrid scaffold (TCP-PCL enhanced with HA) was designed and manufactured using additive manufacturing methods. The printed scaffold was observed under a 40x microscope to assess the printing accuracy. Using a hybrid scaffold that mimics the original defect for a segmental defect is one of the novelties of this study.