The effects of orally taken capsaicin of adipokine expression on adipose tissue

Capsaicin is the pungent extract of red hot pepper. It is considered that Capsaicin uptake might reduce adipose tissue by stimulating lipolysis and also inhibiting lipogenesis. Adipokines are signal carrier proteins from cell to cell and are released from adipose tissue. Besides being involved in the central and periphery tasks, while those tasks are to regulate appetite and energy consumption in the central, its task is to regulate insulin sensitivity, oxidative capacity and lipid uptake in the periphery. In our study, the goal was to identify the potential effects of capsaicin on the expression of some adipokines on the adipose tissue of rats via immunohistochemical staining method. The experiment group (n: 10) was fed with a diet containing 0.04% capsaicin and control group (n: 10) was fed with a standart rat diet. At the end of 60 days, rats were weighed alive and their subcutan, testicular, visceral and brown adipose tissue samples were taken. To all tissues belong to the all groups, leptin, adiponectine, TNFα and visfatin expression were applied via immunohistochemistry method. When examined for Leptin, lesser stain was observed on testicular adipose tissue and visceral adipose tissue in the experimental group compared to the control group. When examined for TNFα, while it was observed that the experiment group was stained more intensely on subcutan and brown adipose tissues compared to the control group, less stain was observed for testicular and visceral adipose tissues. When examined for Adiponectine, while there was no significant difference between control and experiment groups, it was observed that experiment group was stained more intensely on subcutan adipose tissue. When examined for Visfatin, while there was no significant difference on brown adipose tissue between 2 groups, it was observed that testicular, visceral and subcutan adipose tissues were stained more intensely compared to the control. Consequently, Capsaicin caused difference on the expressions of white and brown adipose tissues and some adipokines released from them (adiponektine, leptin, TNF-α and visfatin) by stimulating all those. Keywords: Capsaicin, Adipokines, White adipose tissue, Brown adipose tissue.