Effect of estrogen replacement theraphy on microalbuminuria

Fifty-eight patients who had been undergone total abdominal hysterectomy and bilateral salpingo-oopherectomy due to benign gynecologic disorders were enrolled in this present study. The once who had no contraindication for ERT were randomised in two groups. Group I received transdermal estrogen (Climara TTS) or oral conjugated estrogen (Premarin 0,625 mg), group II did not. Microalbuminuria, creatinine clearance in 24 hour urine specimen and plasma lipid-lipoprotein levels were compared preoperatively and postoperative 1st and 6 th months respectively. At the end of six month of observation in the group who were in surgical menopause and given ERT, statistically significant decline in microalbuminuria was observed. However, in the group who were in surgically menopause and did not receive ERT, level of microalbuminuria did not change significantly. In the group who were oopherectomised following naturel menopause, microalbuminuria level changed clinically after ERT but was not stastistically significant. Whereas in the group who were not given ERT, decline in the level of microalbuminuria was seen and this finding is stastistically significant (p<0,05). We concluded that ERT is protective on cardiovasculer system as well as on renovasculer system.