Uv spectrophotometric studies on drug removal by p-alkyl/p-alkoxy substituted bis-carbamate gels

Low molecular weight organogelators are a family of organic molecules capable of gelling organic solvents. Organogelators form a three-dimensional network through non-covalent interactions such as hydrogen bonding, van der Waals interaction, π-π stacking or dipole-dipole interaction. In recent years, significant progress has been made in the design of new gelling agents. Gels of low molecular weight organic compounds have important applications as new organic soft materials. Examples of these areas are drug delivery, cosmetics, sensor systems, phase selective cleaners. Especially phase selective organogelators are of great interest in water treatment and oil spill removal. These organogelators are preferred because they are cheaper and simpler than the methods currently used. In the pharmaceutical sector, gels are used especially in relation to the delivery of drugs. For this purpose, various methods and models have been developed and their application areas have been examined. In this study, p-alkyl/alkoxyl substituted bis-carbamate derivatives were synthesized to utilize their organogels for drug removal properties. Dry (xerogels) and wet gels were used for this purpose and their drug removal abilities were followed by UV spectroscopy. As a result, it was found that p-hexyloxy derivative with three methylene spacer was the best having a capacity for the removal of dexketoprofen trometamol.