The relationship of preinfarct angina and serum sphingosine 1 phosphate levels

Purpose: It has been suggested that sphingosine 1 phosphate may be responsible for ischemic preconditioning according to numerous animal studies. And in dialy life it seem like preinfarct angina is the most viable example of ischemic preconditioning. Our aim is to evaluate the relationship between preinfarct angina and serum S1P levels.Method: Between May 2011 and January 2012, 86 STEMI and NSTEMI patients enrolled the study who were followed in Gazi University Faculty of Medicine Coronary Care Unit. All the patients questioned for preinfarct angina and they divided into two groups of preinfarct angina positive and preinfarct angina negative. The serum levels of S1P at the admittance and at discharge are measured and maximum CKMB and troponin levels are recorded.Findings: 40 patients had preinfarct angina and 46 had no preinfarct angina. The groups were similar according to the bazal characteristics. The admittance serum level of S1p was 0,78 ?M, discharge serum level S1P was 0,91 ?M and maximum troponin level was 2,23 ng/ml in preinfarct angina positive group. The admittance serum level of S1p was 0,45 ?M, discharge serum level S1P was 0,49 ?M and maximum troponin level was 4,37 ng/ml in preinfarct angina negative group(p values espectively 0,014, 0,010, 0,034). There were no statistical significance for CKMB levels and left ventricular ejection fraction between the two groups.Conclusion: Patients with preinfarct angina have higher serum S1P levels than patients without preinfarct angina, significantly. In addition, troponin levels `as an indicator of infarct size? are significantly lower in patients with preinfarct angina.