Pre and post transfusion NO, VEGF ve IGF-1, IGFBP-3 levels in premature infants and their effects on premature retinopathy

Despite all scanning programs and developments in treatment, retinopathy ofprematurity (ROP) is still the major cause of visual loss in premature infants. Severalfactors have been claimed to be cause of multifactorial ROP since 1942 when firstrecognised. One the them is erythrocyte transfusion that its role in establishment ofROP has not yet been fully understood.Erythrocyte transfusion effect has been thought to depend on oxidative stressand free radicalls of increased iron load in erythrocyte transfused infants. Bu it hasnot been completely highlighted. On the other hand, NO, VEGF, IGF?1, IGFBP?3level alteration that has been proven to be effective on ROP and affected from bloodoxygen by erythrocyte transfusion and consequently their role on ROP establishmenthas not been investigated so far.n this study, we have analyzed the mediators variation through erythrocytetransfusion and their impact on ROP.n our investigation, we have realised that there is no mediator variationthrough erythrocyte transfusion, however, it augments the frequency of ROPincidence. So, we have recommended fresh works for better understanding ofrelationship between erythrocyte transfusion and ROP incidences.At the same time, in advanced phase infant ROP incidence subjects with earlystage IGF?1 30 ng/ml has been found to be under critical level and stressed onceagain on the importance of early stage nutrition.