Relationship between alfa-actinin-3 codon 577 (R577x) angiotensin-1 converting enzyme insertion/deletion polymorphisms in professional, amateur Turkish athletes and sedentaries with performance

Elite athletic performance is a complex phenotype determined by various factors such as physiological, psychological, diet, physical exercise and sociocultural factors. This study aims to investigate the insertion/deletion of the ACE gene and ACTN3 gene R577X polymorphisms in national and amateur athletic athletes and sedentaries and to evaluate the related polymorphisms in terms of athletic performance. Therefore, objectives of the our study were: to examine the genotypic frequencies of the ACE I/D, ACTN3 R577X polymorphisms, endurance performance and power/strength-related phenotypes. To our study, participated voluntarily; 12 short-distance national athletic athletes, 10 short-distance amateur athletic athletes, 6 middle-distance national athletic athletes, 6 middle-distance national athletic athletes and 5 long-distance national athletic athletes, 11 long-distance amateur athletic athletes. Genetic infrastructure of athletes, determined by used such as Restriction fragment length polymorphism (RFLP) and Polymerase chain reaction (PCR) after isolated DNA by used commercial kit. As a results of our study, the highest frekans were found % 60 ACE II and % 70 ACTN3 RX in short-distance amateur athletic athletes, % 50 ACE DD and % 75 ACTN3 RX in short-distance national athletic athletes; % 66,7 ACE ID and % 100 ACTN3 RX in middle-distance amateur athletic athletes, % 66,7 ACE II and % 66,7 ACTN3 RX in middle-distance national athletic athletes; % 54,5 ACE DD and % 81,8 ACTN3 RX in long-distance amateur athletic athletes, % 80 ACTN3 RX and % 40 ACE II-ID genotypes. In the sedanter group we used to compare with athletic athletes, the frequency of the ACTN3 RX and ACE II genotypes was the highest at 52.9% and 50.0%. According to these results, conducted this research we think that ACTN3 R577X and ACE I/D polymorphism distributions in Turkish athletics athletes will be informative in terms of the effects on athletic performance. Keywords: Endurance Capacity; Power/Strength; ACE; ACTN3; Athletic Performance