Comparison between E-cadherin and Beta-catenin expression and Gleason grading system and the other prognostic factors in prostatic carcinomas

Gleason Grading System has been the most significant prognostic factor of prostatic carcinoma for over forty years. The Gleason grading system, which has not changed in years with only a few modifications in pathologyIn this study, gleason grading system, as well as other prognostics factors and two adhesion molecules E-cadherin and Beta-catenin expressions were investigated in cases with radical prostatektomy in Gazi University, Faculty of Medicine faculty between 2003 and 2008E-cadherin and Beta-catenin expressions, evaluated by immunhistochemistry with tissue microarray analyses, were significantly decreased in cases with high gleason grading scores. In addition; expression of adhesions molecules were reduced in cases with invasion of seminal vesicule and outside the prostate. All these findings were consistent with recent literature, and indicate that decreased expression of E-cadherin and Beta-catenin may play a role in progression of prostatic carsinomaIt has been showed in this study that the prognostic factors like capsuler invasion, invasion to seminal vesicule, invasion outside the prostate, perineural invasion and tumor size were correlated with high Gleason grading system scoresFinally; we found that there was a considerable relationship between adhesion molecules, other prognostic factors and Gleason Grading System.