Determination of racecadotril in tablets by ultra-performance liquid chromatography method
2019
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Advisor: Prof. Dr. Armağan Önal
Abstract (EN)
In this study, a simple and selective UPLC method for the determination of racecadotril in pharmaceutical dosage forms has been developed. The method is in reverse phase C18 column; based on the chromatographic analysis of racecadotril with acetonitrile-water (70:30, v / v) mobile phase at a flow rate of 0.7 mL / min. the most suitable wavelength for racecadotril has been determined 220nm. The linearity range for racecadotril was found 5-100 μg / mL. This method was applied to the analysis of racecadotril drug substance in tablets. The results were evaluated statistically. The developed method is easy, precise and repeatable and can be used safely in racecadotril pharmaceutical dosage forms analysis. Keywords: Racecadotril, Ultra-performance liquid chromatography, Pharmaceutical Dosage Form Analysis, Validation, Degredation Product.
Author
Dr. Emrullah Binay
How to Cite
Emrullah Binay (Master Thesis). Determination of racecadotril in tablets by ultra-performance liquid chromatography method, 2019, İstanbul University.
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