Protective effect of boric acid on liver damage in rats with sepsis model

Endotoxic shock (sepsis) is a serious complication that is one of the factors characterized by hypotension, weak tissue perfusion and multiple organ failure and causing death in lying patients. Although many strategies have been developed in the understanding and treatment of endotoxins generated by endotoxins, especially lipopolysaccharide (LPS), many strategies are developed in the understanding and treatment of the pathophysiological mechanisms, it is still a major problem of intensive care units. Boric acid, which is a part of our daily diet; It is one of the most common forms of boron element; Boron is always taken as boric acid to the body and is present in this form in plasma. Some epidemiological data prostate cancer in men of boric acid; It points out that it reduces the incidence of cervical and lung cancer in women. Boric acid is a product that is common in nature and is often used in agriculture, industry and cosmetics as well as traditional medicine applications. Boric acid is rapidly absorbed and dispersed into all body fluids through passive diffusion. Some studies show that the blood tissue distribution rate of boric acid in both human and rats is 1: 1. Experimental studies with boric acid; Dose -dependent shows that boric acid reduces cell proliferation and stimulates apoptosis in some prostate, melanoma and gastric cancer cell lines. In this study, it is aimed to determine the protective efficiency of boric acid in the rats of boric acid, which has been very effective in the immune system, bone development, hormone metabolism and especially in the antioxidant system. In the study, Wistar Albino type (weighing 200-300gr) will be used. LPS Applied Groups 10 Animals, Control Groups 6 Animals are planned to work with a total of 32 animals