Which one is effective in experimental endotoxin-induced uveitis: Sistemic Infliximab, intravitreal infliximab or combine?

The aim of this study was to evaluate the efficacy of sistemic, intravitreal and sistemic-intravitreal infliximab and to compare different treatment modalities.Thirty white New Zealand rabbits were divided into 5 groups, each group had 6 rabbits. Grup 1 received intravitreal (İV) injection of lipopolysaccharid (LPS), grup 2 received İV injection of LPS and İV saline, grup 3 received İV LPS and İV 2mg/0,1cc infliximab, grup 4 received İV LPS and 5mg/kg intravenous infliximab and grup 5 received İV LPS and intravenous 5mg/kg infiliximab and İV 1mg/0,1cc infliximab simultaneously. Inflamation was determined by clinical examination, measuring the protein and TNF- ? concentration and histopathologic examination.Clinical examination score was lower in group 3, group 4 and group 5 and when compared group 1 and 2 (p<0,05). However, there was no statistically significant difference between group 3, 4 and 5 with regard to clinical examination. In group 3, 4 and 5; the protein and TNF- ? concentration in aqueous and vitreus was measured lower than grup 1 and 2 (p<0,05). Altough group 4 had lower protein and TNF- ? concentration than group 3, there was no statistically significant difference. The lowest protein and TNF- ? concentration was detected in group 5 and the difference was statistically significant when compared the other groups. In histopathologic examination, there was no statistically significant difference between grup 1, 2 and 3, however enflamation was determined lower in group 4 and 5 (p=0,14).Intravenous infliximab infusion was effective than intravitreal infliximab in an acute period, in additon simultane intravenous infliximab infüsion and intravitreal infliximab injection can be used as an alternative therapy for acute uveitis.