Analysis of maternal thrombophilia in recurrent pregnancy loss with real-time PCR

Although there are various reasons in the etiology, a determinable reason can be detected only in 50%of the cases. Thrombophilia plays an important role in multiple abortus ethiology. Hereditary thrombophilias cause a problem in tissue and organ system and eventually cause venous thromboemboly, cerebrovascular accidents, myocardial infarction, pulmonary thromboembolism and accordingly placentation anomalies, some specific disorders like perinatal complications and recurrent early pregnancy losses occur. In this study, 302 patients who were admitted to Adnan Menderes University School of Medicine Hospital with the complaint of two or more recurrent pregnancy loss between January 2012 and December 2013 were studied and who has no chromosomal abnormalities in previous analysis. The most common causes of Pregnancy-related venous thromboembolism are factor-V Leiden (FV-L), prothrombin G20210A and methylenetetrahyrofolate reductase (MTHFR) gene mutations. Multiple gene mutations are more important and worthy in the etiology of recurrent pregnancy loss when compared to single gen mutations.The combination of two or more thrombophilic gene mutations might be discussed in the future to evaluate the high risk couples with recurrent pregnancy loss.