The effect of diabet treatment on oxidative stres and carbohydrate-deficient transferrin (CDT) ın diabetic patients

XIVSUMMARYThe Effect of Diabet Treatment on Oxidative Stres and Carbohydrate-Deficient Transferrin (CDT) ın Diabetic PatientsDiabetes mellitus (DM) is a chronic, progressive disease come out as a resultof the absolute or the relative lack of endogenous insulin or ineffectiveness ofit. Insulin resistance means the defect in the biological response to theeffects of exogenous or endogenous insulin and it is one of the main reasonsin the pathophysiology of type 2 DM. Metformin and rosiglitazone show theirmain antidiabetic effects by reducing insulin resistance.The objective of this study is investigating whether CDT used as anindicator of alcohol intake may be used as a new parameter in the follow-upof Diabetes Mellitus (DM).For this purpose, the patient group including fifteen patients (under 70years old; 9 female, 6 male) with Type II DM and the control group includingfifteen healthy volunteer (under 70 years old; 9 female, 6 male) were includedin the study. Metformin (2 g/day) or rosiglitazon (8 mg/day) treatments wereapplied for the patients included in the study.Blood samples were drawn from the patients before the treatment, 3and 6 months after the beginning time of the treatment. In all the bloodsamples of the patient and the control groups, Malondialdehyde (MDA),protein carbonyl, sulfhydryl (SH) groups, nitric okside (NO), CDT %, glucose,fructose amine, HbA1c levels were measured and insulin resistances werecalculated.As a result of the studies performed, in the patients with DM increasedMDA, NO, glucose, fructose amine, HbA1c and insulin resistance levelswere observed when compared with the control group. Although serumsulfhydryl and carbonyl levels showed a prominent decrease in the 3th andthe 6th months before the treatment, no significant difference was observedbetween the patient and the control groups. No significant difference wasobserved in the CDT % and the insulin levels of the diabetic patients.XVAccording to these results, in diabetes it was seen that lipidperoxidation was increased and this affected the antioxidant mechanisms.This made us think whether the reason of the decrease in the oxidativestress was due to the decrease of hyperglycemia after the treatment or dueto the intake of antidiabetic drugs with antioxidant properties.Key words: CDT, Type II DM, oxidative stress.