Türk popülasyonunda DNA onarım geni ERCC1 polimorfizmi ve glioma duyarlılığının araştırılması

Glioma, which account 26% of CNS cancer and 80% of malignant primary brain, involve histologically many different types of tumors that have several distinct etiologies. Since ERCC1 is a crucial protein in NER mechanism and affects instability of the genome, ERCC1 variation might influence humain tumors. Therefore, in this learning we studied the connection between ERCC1 SNP rs11615 and glioma with 40 controls and 34 cases groups. We performed RT-PCR for genotyping analysis and statistics analysis to compare the significance differences between the groups. According to our results, in controls groups AA genotype 27% ( 10 out 40), AG genotype 43,2% ( 16 out 40) and GG genotype 29,7% ( 11 out 40) were found. AA genotype 27,3%, ( n=9), AG genotype 36,4% (n=12) and GG genotype 36,4% (n=12) were distributed in the glioma patients. No significance difference was observed between groups with p value, 0.802. Further studies with big amounts of patients are required to investigate exact association. Key words: glioma, ERCC1, polymorphism