Investigation of CTLA 4 and MYG1 gene polymorphisms on vitiligo patients

Vitiligo is a disease characterized by sharply limited white macular depigmentation as a result of melanocyte loss. Disease is divided into three types according to prevalence and localization as localized, general and universal. Etiology of vitiligo is unknown, but clearly shows a komplex structure. Genetic predisposition, stress, many influencing factors such as systemic diseases and physical trauma causes vitiligo. In our study, MYG1gene rs1465073 andve CTLA4 gene rs231775 polymorphisms were evaluated in 106 patients diagnosed with vitiligo and 97 controls. Age of onset of illness of the patients ranged from 1-65 years and average age of onset was found 17.64. Ninety one patients diagnosed with vitiligo were characterized according to the vitiligo types and 17 patients (18,6%) was localized, 42 patients was (46,1%) generalized and 32 patients was (35,1%) was universal. Although generalized vitiligo was more frequent in females, there was no significant differences between females and males. Genotyping was performed using real time PCR method. There is no statistically significant differences between patients and controls in terms of allele frequencies of MYG1gene rs1465073 and ve CTLA4 gene rs231775 polymorphisms. Beside, there is no statistically significant differences between patients and controls in terms of genotype frequencies of CTLA4 gene rs231775 polymorphism. On contrary to this there is statistically significant differences between patients and controls in terms of genotype frequencies of MYG1gene rs1465073 polymorphism. In conclusion, consistent with the literature data, there is a significant association between MYG1gene rs1465073 polymorphism and vitiligo. But there is no directly association between CTLA4 gene rs231775 polymorphism and vitiligo.