Yeni karbamoil sübstitüe indolizinlerin azometin ilidlerin 1,3-dipolar halkasal katılma reaksiyonları üzerinden sentezi

This study focused on two important issues. Preparation and study of N-substituted 8-Hydroxyquinoline derivatives for cycloaddition reactions was the first of these issues. The second issue of the actual scope of the thesis was synthesis of new carbamoyl substituted indolizines via 1,3-dipolar cycloaddition reactions of azomethine ylides. Four types of azomethine ylides were prepared in situ from pyridinium chlorides which were tested with various olefinic and acetylenic dipolaraphiles such as dimethyl acetylenedicarboxylate, diethyl acetylenedicarboxylate, vinyl acetate, diphenyl acetylene and phenyl acetylene. Theoretical calculations of HOMO, LUMO energy levels of both azomethine ylides and dipolaraphiles constituted an important part of this work. Based on the most resent studies literature, six new carbamoyl substituted indolizines, which were purified by means of thin layer chromatography, were synthesized. The structures of new carbamoyl substituted indolizines were elucidated by means of IR, NMR and physical characteristics (melting points and retardation factors).