Yeni uracil ve o-benzosülfimid esaslı potansiyel biyoaktif heterohalkaların sentezi

The aim of this work is to synthesize a variety of N-(5-methyl-1,2,4-oxadiazolyl) substituted o-benzosulfimide, N,N?-(5-methyl-1,2,4-oxadiazolyl) disubstituted uracil, N,N?-(5-methyl-1,2,4-oxadiazolyl)disubstituted 5-amino uracil, and N,N?-(5-methyl-1,2,4-oxadiazolyl) disubstituted benzylidene pyrimidinedione. 1,2,4-Oxadiazole related scaffolds have been used for decades in composing a variety of heterocylic compounds with a remarkable potency of bioactivity. In order to perform this, firstly we have prepared, 5- chloromethyl 1,2,4-oxadiazoles from the p-substituted benzamidoximes, which were easily synthesized from the p-substituted benzonitriles. To our best knowledge of literature, N- oxadiazolylmethyl substituted O-benzosulfimide, N-oxadiazolylmethyl substituted uracil, N-oxadiazolylmethyl substituted 5-amino uracils, and N ?oxadiazolylmethyl substituted pyrimidines have not been reported so far. 5-Chloromethyl-1,2,4-oxadiazoles were reacted with the above mentioned benzosulfimide, uracil which have N-H, by using K2CO3 in DMF. These structures of all end products were elucidated by means of IR, NMR (1H, 13C), LC-MS spectra and physical data (melting points and Rf values). Since all of these novel compounds carry potent groups like oxadiazole, bioactivity assessment of these heterocyles are underway in due course.