Synthesis of 2-[ 4-acetylphenoxy]-2-oxoethyl methacrylate monomer and its polymer

ABSTRACTM. Sc. ThesisSYNTHES S OF 2- [ 4-ACETYLPHENOXY] -2-OXOETHYL METHACRYLATEMONOMER and TS POLYMERMuhammet UYGUNAfyon Kocatepe UniversityGraduate School of Natural and Applied SciencesChemıstrySupervisor: Assoc. Prof. Dr brahim EROLIn this study, 4-acetyl chloro acetat (AFKA) was prepared by reaction of 4-hydroxyacetophenon and chloroacetyl chlorid in the presence of potassium carbonate at the0 0C in dicholoro methane solvent. 2- [ 4-Acetylphenoxy] -2-oxoethyl methacrylatemonomer (AFEMA) was synthesized by reacting AFKA with sodium methacrylate inacetonitrile as solvent. The homopolymerization of AFEMA were carried out undernitrogen atmosphere in 1,4-dioksane solution at 60 OC with by using AIBN as aninitiator. The oxime and thiosemicarbazone derivatives of AFEMA were prepared withhydroxylamine hydrochloride and thiosemicarbazide hydrochloride, respectively. Themonomer, and its homopolymer was characterized by Infrared(IR),13C-NMR and 1H-NMR techniques. Thermal properties of the poly(AFEMA) and its oxime andthiosemicarbazone derivatives were also studied by thermo gravimetricanalysis(TGA). Also, in order to determinate biological activities of polymer were obtained bythe disc diffusions method2007, 53 pagesKeywords: 4-hydroxy acetophenon, Methacrylate, biological activity, oxime andthiosemicarbazon.