Volumetric measurement of the cortical neuroanatomy of pain centers

Pain is a signal that occurs in pathological conditions in the nervous system. Clinical studies have generally been conducted for the etiology of pain in individuals with radiological pain. As is known, in patients with chronic pain such as migraine, due to chronic cerebral flow abnormality due to recurrent ischemia, significant thinning and volume loss were observed in the measurements made to the pain centers. Volumetric studies with cortical centers in normal individuals are limited in the literature. In this study, our aim is to perform whole brain morphometric analysis of pain centers radiologically in normal individuals and to evaluate the values ​​obtained from cortical structural models for diagnostic biomarker research in further studies. Thus, it is to provide standardization to the volumetric values ​​of pain centers in normal individuals. In our study, normal individuals aged 18-65 years who do not have any additional disease (without systemic, intracranial pathology, psychiatric disease) and who do not have pain will be included in our study. The examinations made with 1.5-T magnetic resonance (MR) will be examined radiologically in 3 different dimensions (in 3D volumetric sequences). The volumetric analysis of the cortical centers related to pain will be calculated by means of special software. The data to be obtained will be evaluated statistically and how the variability according to gender and age will be examined. In addition, the findings to be obtained may motivate physicians dealing with pain to design new treatment models and new interventions that block these centers, especially in functional neurosurgery.