The relationship between prolidase enzyme activity, IGE and eozinophil levels in children with allergic diseases

Objective: Asthma diseases such as allergic rhinitis, asthma, allergic dermatitis and atopic eczema are among the most common causes of chronic diseases. The prevalence of these diseases is increasing day by day. Prevention and early recognition of these diseases are important. In this study, we aimed to investigate the effect of prolidase activity on allergy patients and the relationship with IgE and eosinophilia. Materials and Methods: Blood samples were collected from 40 allergy patients and 40 age and sex-matched healthy children. Prolidase activity was measured by Chinard method, IgE by ELISA method and eosinophil by flow cytometry. Findings: There was no significant difference in age and gender between the two groups (p> 0.05). VKI was lower in allergy group than control group (p <0.05). Prolidase activity, IgE and eosinophil levels were found to be higher in the allergy group than in the control group (142,13 ± 54,39 U / L, 134,57 ± 168,13 IU / L and 445,15 ± 450,45 for the asthma group and the control group, 94,30 ± 45,28 U / L, 38,54 ± 58,13 IU / L and 180,58 ± 69,84 for the control group). There was no statistically significant relationship between prolidase and IgE and eosinophil in allergy group (p> 0,05), but there was a positive correlation between IgE and eosinophil (p <0.05). Conclusion: In addition to the IgE and eosinophil levels routinely evaluated in the diagnosis of allergy, the increase in prolidase activity is becoming increasingly important. We believe that the increase in prolidase activity may be used as a differential criterion for distinguishing asthma as an allergic or asthma that develops after recurrent bronchitis. Because of the decrease in prolidase activity in asthma due to chronic bronchitis, the production of collagen tissue is increased, whereas prolidase activity is observed to be increased in allergic asthma cases.