The synthesis of amino sugar derivates

ABSTRACTIn this study, D-glucose, D-galactose, D-arabinose and 1,2-O-isopropylidene-α-D-glucofuranose were used as a starting sugars. The experimental works were constituted on thesynthesis of amino derivatives of these simple sugars. 1,2-O-isopropylidene-α-D-glucofuranose,β-chloralose ( 1,2-O-(S)-trichloroethylidene-α-D-glucofuranose ) and α-chloralose ( 1,2-O-(R)-trichloroethylidene-α-D-glucofuranose ) were obtained commercially available. The compoundof arabinochloralose were prepared from the reaction of arabinose with chloral. Tosil derivativeof 1,2:3,4-di-O-isopropylidene-α-D-galactopyranose was obtained and than it was converted tothe azide form by following the nücleophilic substitution reaction. Obtained azide formation wasreacted with various reducing agents in order to get the related amino sugar derivative. Assimilarly, amino sugar derivatives of arabinochloralose and 1,2-O-isopropylidene-α-D-glucofuranose were obtained by using with the same chemical methods. In addition, tosilationreactions of β-chloralose and α-chloralose were also studied. The experimental studies is stillgoing on to convert the azide formation of these tosil derivatives for being able to prepare therelated amino sugar scaffolds.