Analysis of paraoxonase-1 gene in small for gestational age neonates using molecular techniques

In developed countries, there are a number of studies on the identification, diagnosis and treatment of risk factors responsible for pregnancies resulting in small for gestational age neonates. Although this problem is much more important in developing and underdeveloped countries, there are very few studies in this area and the majority of these studies are insufficient in terms of method and statistical evaluation. In the present work, the PON1 (rs662 and rs705379) gene polymorphisms were examined by broad DNA sequence analysis in small for gestational age neonates and the variation of PON1 gene polymorphisms were determined. The blood samples of SGA babies were taken from Cukurova University Balcali Hospital, Neonatal Intensive Care Unit in first three days of birth. The study analysis was done on 41 SGA neonates by the RT-PCR procedures. As a conclusion, because of small number size of cases used in this study, many studies are required using a large number size of SGA neonates.