The synthesis of 1-(benzo[d]thiazol-2-yl)-3-(3-nitrophenyl)-1H pyrazole-4-carbaldehyde having anticancer activity potential and its investigation for the further stage reactions with various nucleophiles

Two adjacent atoms and comprising five membered ring structure of the molecule, characterized by pyrazole, have become a common center for many pharmaceutically active compounds, because there are significant properties as pharmeutical active ingredient. Many drugs or patented drug candidates have been developed as a result of biological activity studies, using the pyrazole ring in recent years. In this study, synthesis of new pyrazole derivatives containing a thiazole group is aimed. For this, fhirstly, synthesis of 1-(benzo[d]thiazole-2-yl)-3-(3-nitrophenyl)-1H-pyrazole-4-carbaldehyde molecule, which is our starting compound, has been carried out. Then the compound of pyrazole aldehyde which is obtained has been converted to the new thiosemicabazone, interacting with various thiosemicarbazide. Reaction of virialisation of these synthesised compounds has been in a acetic anhydride environment. At the same time reactions of advanced step of pyrazole carbaldehyde which is our starting compound have been carried out with various nücleophilic reagents. The structures of the synthesized compounds have been characterized with the help of same spectroscopic methods (FT-IR, 1H-NMR, 13C-NMR and Mass) Keywords: Pyrazole, Pyrazole Carbaldehyde, Sulfonamide, Thiosemicarbazide, Thiosemicarbazone.