Synthesis, characterization and antibacterial activities of some aromatic methanesulfonylhydrazone derivatives and their Ni(II), Pd(II) and Pt(II) complexes

In this work, methanesulfonic acid hydrazide and its derivatives salicylaldehydemethanesulfonylhydrazone (salmsh), 2-hydroxyasetophenone methanesulfonylhydrazone(afmsh), 2-hidroxy-3-metoxybenzaldehydemethan sulfonylhydrazone (o-vanmsh) have been synthesized. The structures of methanesulfonylhydrazone derivatives have been characterized by elemental analysis and spectroscopic methods ( FTIR, 1H-NMR.UV-vis). Complexes of methanesulfonylhydrazone derivatives have general formule ,as [ML2] (M=Ni(II), Pd(II) and Pt(II)) and their structures have been determined by using elemental analysis, FTIR, LC/MS spectra, magnetic susceptibiliy and molar conductivity methods. The antibacterial activities of the compounds have been determined in vitro against gram positive bacteria; Staphylococcus aureus ATCC 25923, Bacillus cereus RSKK 709,, and gram negative bacteria; Pseudomonos aeruginosa ATCC 27853, Escherichia coli ATCC 35268 by paper disc diffusion and microdilution methods. In General; antibacterial activities of complexes were observed more active than ligands.Key Words : Hydrazide, sulfonylhydrazone, Ni(II), Pt(II) and Pd(II) complexes, antibacterial activite.