Synthesis of some novel purine derivatives and investigation of their biological activity

In this study, a series of (6-amino-9H-purine-9-yl)alkanenitrile purine compounds having different alkyl cyano groups at position 9 of adenine were synthesized. 9-(Chloroalkyl)-9H-purine-6-amine compounds having different chloroalkyl groups at position 9 of adenine were also synthesized. Synthesized 9-(chloroalkyl)-9H-purine-6-amine compounds were reacted with potassium thiocyanate and potassium selenocyanate to give 9-(thiocyanotoalkyl)-9H-purine-6-amino and 9-(selenocyanatoalkyl)-9H-purine-6-amino, respectively. Synthesized cyano, thiocyano and selenocyano functional adenine derivatives were converted the tetrazole rings with sodium azide and amonium chloride. The structures of the synthesized compounds were confirmed by spectroscopic techniques (FT-IR, 1H-NMR, 13C-APT, 13C-NMR, HR-MS). The antimicrobial activity of the synthesized compounds and the effect of the compounds on DNA were investigated.