Genotoxic activity of essenstial oils and monoterpenes studies

iABSTRACTMaster of Science ThesisGENOTOXIC ACTIVITY OF ESSENSTIAL OILS ANDMONOTERPENES STUDIESADALET KILIÇAnadolu UniversityGraduate schooll of SciencesBiology ProgramSupervisor: Assist.Prof.Dr. Berrin AYAZ TÜYLÜ2005, 60 pagesEssential oils and isolated from its terpenoid compounds of extractedfrom various plants have different biological activities. In this case, they areused in aromatherapy, cosmetics, food and drug industries. In this study,genotoxic activity of some essential oils and monoterpenes obtained fromsome plants investigated with HPRT gen mutation assay in humanlymphocytes. According to the results, thym essential oil have efficient HPRTgen mutation activity due to increase of variant frequency at all of the doses.Also, its compounds carvacrol has slight HPRT activity but thymol hasnegative effect. It was resulted that other test compounds bay-leaf, salveessential oil and cineol-1,8 cause the HPRT gene mutation at highconcentrations by increase of variant frequency values.Keywords: Essential oils, Monoterpenes, HPRT, Human Lymphocytes,Genotoxicity