Frequency of sarcopenia in diabetic and non-diabetic chronic kidney patients using bioempedance analysis and comparison with the normal popülation

Introduction and Purpose: Sarcopenia is a disease area that has become increasingly important both in the world and in Turkey in recent years. Since there are not many studies comparing diabetic and non-diabetic chronic kidney disease (CKD) and normal population with the bioimpedance analysis (BIA) method, it is aimed to contribute to the literature on this subject and to increase awareness of sarcopenia with the results obtained and to benefit the follow-up of patients. Materials and Methods: The study included 60 diabetic CKD, 60 non-diabetic CKD and 60 control patients without chronic disease, who were over 40 years old and applied to Manisa Celal Bayar University Hafsa Sultan Hospital Nephrology and Endocrinology Polyclinic. There were 30 female and 30 male participants in each group. In addition to recording the laboratory parameters of the patients, anthropometric measurements, hand grip strength test with dynamometer, SARC-F survey, BIA measurement and TUG test were performed. Results: Sarcopenia was detected in 22 (12.2%) of the patients. In the patient groups, sarcopenia was detected in 14 (23.3%) patients with diabetic CKD, 7 (11.7%) patients in non-diabetic CKD and 1 (1.7%) patient in the control group, and a statistically significant difference was found between the groups. Used to evaluate muscle strength and quality between groups; While handgrip strength (ESG) and skeletal muscle quality (ESG/SCC) values were found to be significantly lower in the diabetic CKD group compared to other groups, SARC-F score and TUG test were found to be significantly higher in the diabetic CKD group compared to other groups. In subgroup analyses, while this significance continued in women, it was observed that it lost statistical significance in men, except for the TUG test. Correlation analyzes showed that skeletal muscle quality and spot urine protein/creatinine ratio were inversely proportional. It was observed that GFR was inversely proportional with the TUG test. Conclusion: Our study showed that muscle strength, muscle mass, muscle function and muscle quality were lower in diabetic CKD patients than in non-diabetic CKD patients and the control group without chronic disease. It has been determined that muscle function and muscle quality decrease with the decrease in GFR and increase in proteinuria. In diabetic patients, it has been shown that muscle function and muscle quality decrease as fasting blood glucose and HbA1c increase. Key Words: Diabetes Mellitus, Chronic Kidney Disease, Sarcopenia, Skeletal Muscle