The effects of erdosteine on experimental acute pancreatitis model

ABSTRACTAcute pancreatitis is a disease which can manifest itself with a wide range of clinical presentations from self-limiting mild symptoms to fulminant course with multiorgan failure.In this study, 30 male Wistar albino rats were divided into 3 groups, with 10 rats in each group. No action was taken in Group 1. An experimental pancreatitis model was formed with the rats in Groups 2 and 3, which were given subcutaneous cerulean injection of 80 ?g/kg in total administered in 6 doses every one hour, and blood amylase and lipase values were assessed for confirmation. Erdosteine 10 mg/kg was administered via orogastric route in the rats in Group 3. This treatment was continued for another 2 days and the rats were sacrificed on the 3rd day. The pancreas tissues removed from the rats were examined histopathologically for edema, inflammation, fat necrosis, acinar necrosis and vacuolization, and the evaluation was made by scoring between 0 and 4.At the end of the biochemical examination of amylase and lipase values and the histopathological examination of pancreas tissues, it was concluded that the rats developed acute pacreastitis by cerulean use, and serious edema, inflammation, acinar necrosis, fat necrosis and vacuolization were observed in the pancreas tissue. In the rats in Group 3, Erdosteine had the expected anti-inflammatory effect, and the histopathological results showed a reduction in pancreatitis severity. According to the statistical results of the study, Erdosteine resulted in significant reductions in the inflammation, acinar necrosis, fat necrosis and vacuolization scores in acute pancreatitis tissues.Consequently, severe pancreatitis was created by cerulein in the rats, and pancreatitis severity was reduced by the use of Erdosteine. If these favorable results obtained by Erdosteine are supported by more comprehensive experimental and clinical studies, Erdosteine can be used as a new treatment method with favorable effects in the treatment of acute pancreatitis.