The effect of bevacizumab on corneal neovascularization in experimental rabbit model

This study carried out at Gazi university research center. Total of 20 New Zilanda type rabbits were included in this project. After performing a model of cornea neovascularization the rabbits were divided into 4 groups. In the 1st group 12.5mg/ml topical Bevacizumab, 2nd group 4mg subconjunctival Bevaciuzmab, 3rd group 10mg subconjunctival Bevacizumab and in the 4th group no medication were given. Corneal photograph, tear film and aqueous humors samples were taken every 2 days. VEGF level assessed from the samples. By the end of 14th day euthanasia performed and the rabbits cornea were excised. After staining the corneas number of vessels per section were denoted. The amount of neovascularization was lesser in the 1st, 2nd and the 3rd groups. Although no difference in between 2nd and 3rd group was found they were lesser than 1st group. The eyes receiving Bevacizumab showed lesser amount of VEGF level in their tear film and aqueous fluid when compared with control group. The number of vessels per microscope section was fewer in the Bevacizumab treated eyes.