Preparation and characteri̇zati̇on of electrospun plga/soluble eggshel membrane protein nanofibers for tissue regeneration

To provide the appropriate conditions for wound healing, wounds often require a dressing or a clothing from a suitable material. It is expected that these materials have to protect the wounded tissue and enhance the wound healing process. In traditional Chinese medicine egg shell membrane (ESM) knowns as 'phoenix cloth' and have been used to cure for centuries. Creams containing dexpanthenol have been widely used to treat mucous membrane lesions and skin wounds. Electrospinning is a fast and easy way to produce nanofibers. In addition to allow producing scaffolds like extracellular matrix, electrospinning technique is promising for producing drug loaded wound dressings. In this study, with using poly (lactic-co-glycolic acid), PEO (Polyethylene oxide), and PCL (Polycaprolactone) in electrospinning method, we developed a novel bioactive wound dressing formulation with soluble eggshell membrane protein, and dexpanthenol. For this purpose, drug release from the matrix, swelling test, morphological examining with electron microscope imaging and mechanical strength tests with texture profile analyser have been done.