Production and characterization of wound dressings containing postbiotic using electrospinning method

Wound dressings are medical textiles that significantly impact the wound healing process by preventing chronicity and controlling exudate, thereby aiming for faster healing. Since each wound is characterized by its unique properties, the use of a single type of wound dressing is impractical. Nanofiber wound dressings, with their large surface area and highly porous structures, maintain moisture balance while also serving as barriers against external pathogens. The electrospinning method allows for the incorporation of various functional components into the structure of nanofibers. Postbiotics, which are bacterial metabolites that do not contain live cells, enhance the overall health of the wound surface by regulating inflammation and promoting tissue regeneration through their diverse physiological activities. In this study, antimicrobial nanofibers applied to the wound surface serve the purpose of protecting the wound from infection and accelerating healing. In this study, the feasibility of incorporating postbiotics derived from Lactobacillus acidophilus and Lactobacillus rhamnosus strains into the structures of polymer nanofiber mats produced via the electrospinning method, as well as the antimicrobial activity of these nanofibers, was analyzed. The findings from the characterization methods applied to the produced nanofibers demonstrated that postbiotics could be successfully incorporated into the nanofiber mats and provided good antimicrobial efficacy against five different pathogenic microorganisms.