Retrospective analysis of patients diagnosed with early stage hodgkin lymphoma

Aim: The aim of this study is to retrospectively evaluate various characteristics of early-stage Hodgkin lymphoma patients including age, gender distribution, prognostic factors, laboratory and clinical features, histopathological differences, treatment response, and treatment-related complications. Additionally, the study aims to assess the impact of radiotherapy on survival, as well as differences in progression-free and overall survival between patients receiving combined modality treatment and those receiving chemotherapy alone, stratified according to different guidelines into favorable and unfavorable early-stage Hodgkin lymphoma patients. Materials and Methods: Data were obtained from 199 classical Hodgkin lymphoma (cHL) and 14 nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) patients, with a total of 213 early-stage Hodgkin lymphoma cases. Demographic, clinical, histopathological, and laboratory characteristics, as well as treatment protocols and doses, treatment responses, and treatment-related complications, were collected. Progression-free and overall survival were calculated. cHL and NLPHL were evaluated separately throughout the study. Results: Of the cHL patients included in the study, 50.8% (n=101) were male, with the most common subtype being nodular sclerosis (100 patients, 50.3%), while mixed cellularity subtype was more common with increasing age (p<0.001). Distribution of stages observed were 31 cases of stage IA, 1 case of stage IB, 104 cases of stage IIA, and 63 cases of stage IIB. According to EORTC, overall survival (OS) was significantly higher in favorable cases, while according to NCCN, progression-free survival (PFS) was significant between favorable and unfavorable groups, with no difference observed in other groups (p=0.046 and p=0.044, respectively).