Prognostic impact of p16 and p53 gene expressions in stage 1a epithelial ovarian cancer

Epithelial ovarian cancer(EOC) is the most lethal gynecological cancer in developed and developing countries. Whereas at early stages prognosis is better and 5-year overall survival is higher than %90. It is shown that some proteins(eg. P53,p16) are prognostic especially at advanced stages. Based on this information in this study comparison of p16 and p53 expression's prognostic importance with other conventional parameters in stage Ia 29 EOC cases is planned. Appropriate examples in parraffin blockes were treated with p16 and p53 immunohistochemical staining. Age, grade and hystologic type are the conventional parameters and compared with the p53 and p16 results. Univariant ve multivariant analysis indicated that p16 and p53 expression increased with grade but, due to the limited number of cases, p16 and p53 expression and other conventional parameters haven't been determined as prognostic. Larger case series in uniform patient groups may contribute to the literature.