Famotidinin elektrokimyasal davranışı ve ilaç tabletlerinde tayini

Voltammetric behavior of Famotidine (FMD) selected as test material was investigated on a pencil graphite electrode (PGE) by using cyclic and differential pulse voltammetric techniques for the purpose of contributing to voltammetric determination of Famotidine to improve very few voltammetric studies in the literature. First of all the voltammetric behavior of FMD was examined by using cyclic and differential pulse voltammetric techniques at different working electrodes. Voltammetric parameters, such as, starting potential, scan rate were optimized. The change of FMD peak currents at PGE was examined against the pH of supporting electrolyte and the concentration of FMD by using DP voltammetry. The calibration graph under the optimized conditions consisted of two linear segments of 8.0×10-7 – 3.0×10-5 M and 5.0×10-5 – 1.0×10-3 M. The content of FMD in Famoser Drug (40 mg FMD in per tablet) was tried to be determined by using DP procedure under the optimum conditions. For this aim, standard additions methods were used. The obtained results were good agreement with the manufacturer's declared FMD content in a Famoser tablet.