Evaluation of chromogranin A level in pregnant women with gestational diabetes

SUMMARY EVALUATION OF CHROMOGRAIN A LEVEL IN PATIENT WITH GESTATIONAL DIABETES Dr.Tülay Semiz Aim: Gestational diabetes is defined as varying degrees of glucose intolerance disorder first detected during pregnancy. Its frequency is increasing worldwide. It is associated with adverse complications for both mother and fetus. There is no consensus on diagnosis, and a single-stage or two-stage oral glucose tolerance test can be used. Studies have found that there is a correlation between Chromogranin A values measured in plasma and gestational diabetes, and significantly higher results are obtained compared to healthy pregnant women. In this study, we aimed to determine whether the Chromogranin A level in plasma in gestational diabetic pregnant women could be a parameter that helps us diagnose gestational diabetes. Material-Method: Our study was designed as a prospective clinical study; It was selected among the pregnant women who applied to Pamukkale University Faculty of Medicine Gynecology and Obstetrics Polyclinic and Service. Pregnant women who underwent oral glucose tolerance test at 24-28 weeks were selected. According to the test results, plasma Chromogranin A, AST, ALT, ALP, LDH, GGT, HB, HCT, WBC, PLT, NA, K, MG, CL, FBG levels were measured in 30 patients with gestational diabetes and 30 patients with normal test results. Data were recorded as plasma concentrations. Data were analyzed with the SPSS 24.0 (IBM Corp. Released 2016. IBM SPSS Statistics for Windows, Version 24.0. Armonk, NY: IBM Corp.) package program. Continuous variables are expressed as mean ± standard deviation. Man Whitney U test was used for group comparisons. Student's t test was used for comparison between groups. Results: A statistically significant increase was observed in serum AST and LDH values in the gestational diabetic patient group compared to the control group. (p 0.05 p0.10). A positive correlation between serum Chromogranin A levels and GDM in the gestational diabetic patient group (p 0.178). Conclusion: Our findings show significantly higher AST and LDH levels in the GDM patient group while Chromogranin levels were not significantly different between the groups. Due to the limited number of patients in the study, adequate results may not have been achieved, and further studies are needed in a larger patient population. Key Words: Gestational Diabetes Mellitus, Chromogranin A