An investigation about the most effective antithrombotic regime in preanastomosis period of Gluteus Maximus flaps.

Objectives: To see the effects of thromboprophylactic agentsin in early periodthrombosis of gluteus maximus muscle flaps.Materials and method: Fourty five male Sprague-Dawley rats mean weight289gr were assigned to 1 of 9 treatment groups. Every group had five rats. Thefirst one is the sham group; no agent was used. SC heparin, SC LMWH, oralaspirin and the combinations of these groups with iv heparin, only iv heparininjekted group and the last group; we didn?t give any thromboprophylactic agentbut washed the surgical area with isotonic % 10 heparined. Alsa the other eightgroup without sham were washed during the operation with this solution. Allflaps were elevated by the same surgion. After the elevating procedure the flapswere put in to the %10 formaldehyde solution and taken to the pathology labs.The presence of fibrinogen, vWf and the thrombomoduline was researched intothe flap tissues py pathologist. The result were evaluated by statistically.Results: According to the Immunohistochemical analysis; in the sham groupdiffuse thrombosis was seen. There was found the lowest thrombosis findings inSC Heparin group. A mild or moderate degree thrombosis were seen in the SCLMWH, oral aspirin or iv heparin used group.Conclusion: In this animal model, preoperative sc heparin treatment havefound a significant thrombroprophylactic effects when used individually but notin combination.Keywords: Flap, thrombosis, heparin, LMWH, aspirin