An investigation of antitumor and biological activities of hydroxyurea derivative 1,3,4-thiadiazoles
2010
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Advisor: Doç. Dr. Mustafa Karatepe
Abstract (EN)
In this research, the effect of hydroxyurea derivative 1,3,4-thiadiazoles and its metal complexes on the MDA concentration which is an andicator of lipid peroxidation, antioxidant vitamins A, E, C levels in serum of rats which is injected subcutaneously and antitumour activity in cell culture media were investigated.In the comparision done among groups, it was observed that serum concentrations of vitamins C, A and E were statistically changed, but the serum level of MDA wasn?t statistically changed. In addition to this, cell viability experiments show that thiadiazole components and its metal complexes have effective in vitro antitumor activity.Key Words: 1,3,4-Thiadiazole, Biological Activity, Hydroxyurea, Antitumor Activity, Antioxidants Vitamins (A,E,C), MDA
Author
Yusuf Karagözoğlu
Institution
How to Cite
Yusuf Karagözoğlu (Master Thesis). An investigation of antitumor and biological activities of hydroxyurea derivative 1,3,4-thiadiazoles, 2010, Fırat University.
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