Determination of pesticide residues on some vegatable by using ion mobility spectrometry coupled with LC-MSMS

Multi-residue analysis method was developed for 18 pesticides by using liquid chromatography tandem mass spectrometry (LC-MSMS) and High- Field Asymmetric Waveform Ion Mobility Spectrometry (FAIMS) coupled with LC-MSMS devices.In this study 18 pesticides which were the most used for the agricultural production in Antalya and suitable for liquid chromatographic analysis were chosen. Tomato and cucumber were used as samples for the study and sample extraction was made according to QuEChERS method. Analyses of sample extract were carried out with LC-MSMS initially. Parent ions and product ions of the active substances were determined. Selected reaction monitoring (SRM) and positive ionization mode was used. For the LC-FAIMS-MSMS analysis, FAIMS parameters optimization performed initially according to the active substances and developed LC-MSMS method was used.18 pesticides were studied in LC-MSMS. It was found that it is necessary to determine the device parameters individually for each analyte in LC-FAIMS-MSMS analyses. However, it is not suitable for multi-residue analyses were confirmed. The analysis method developed for both LC-MSMS and LC-FAIMS-MSMS was validated and for the result of method validation parameters were found the acceptable ranges.The comparison studies indicate that the matrix effect largely disappeared with using FAIMS device and the signal to noise (S/N) ratio has been found to be considerably higher than LC-MSMS. It is reported that it can be advantegeous in single or several pesticide residue analyses in complex matrix.KEYWORDS: Food safety, pesticide, LC-MSMS, FAIMS, multi residue analysis