A genotype study about alpha-1 antitrypsin gene in patients with chronic obstructive pulmonary disease

viiiSUMMARYAlpha 1 antitrypsin gene locates in long arm of the 14th chromosome (14q32.1) andconstructed by 5 exon and 4 intron. α1 antitrypsin gene which is 12301 base pair longis expressed in liver and codes α1 antitrypsin protein which is a 52 kDa molecularweight glycoprotein and single polypeptide chain containing 394 amino acids. In thisstudy, 40 male patient? blood samples which have chronic obstructive pulmonarydisease, referred from Afyonkarahisar Kocatepe University Faculty of MedicineDepartment of Respiratory Disease and Afyonkarahisar Respiratory Disease Hospitalto our department were studied. S, Z and M allele genotype were analyzed withPCR-ELISA method. All of patients had PiMM genotype.Data collected from study and literature were combined and interpreted. This studyshows that regional mutation analyses needs to be widespread data collection.PDF created with pdfFactory trial version www.pdffactory.com