Synthesis, Characterization and Biological Activities of 1,2,4-Triazoles containing Coumarin Ring

In the first stage of this thesis study, which was planned in three stages, thiosemicarbazite was obtained by interacting thiophene-2-carbohydrazide with ethyl isothiocyanate. By adding KOH subsequently to the reaction medium; 4-ethyl-5- (thiophen-2-yl) -2,4-dihydro-3H-1,2,4-triazole-3-thione was obtained. In the second stage of the study, 4-ethyl-5- (thiophen-2-yl) -2,4-dihydro-3H-1,2,4-triazole-3-thione obtained in the first step, in dry acetone containing K2CO3, 4- ( chloromethyl) -7-methylcoumarin was converted to 1,2,4-triazole compounds containing coumarin rings by interaction with 4- (chloromethyl) -6,8-dimethylcoumarin and 4- (chloromethyl) -6,7-dimethylcoumarin. These synthesized compounds were experimentally characterized by FT-IR, 1H-NMR and 13C-NMR methods. In the third stage of the study, biological properties such as antioxidant, antimicrobial and cytotoxic properties of the compounds obtained were studied. .