Synthesis of mesoporous silica nanoparticles MCM-41 and SBA-15,surface modification studies with aminoorganoalkoxy silane and boralkoxides and comparison of drug delivery and release parameters

Controlled drug release technology is one of the rapidly advancing scientific areas of chemists and chemistry engineers' research on health. Controlled drug release systems offer numerous advantages over traditional dosage forms, including enhancing drug efficacy and biocompatibility, reducing toxicity and dosage, improving patient compliance and patient comfort. Mesoporous silica nanoparticles (MSN) are of great importance as support materials for controlled drug release systems because of their large surface area, large pore volume, thermal stability, bio-compatibility and the ability to modify pore surfaces. In this study, MCM-41 and SBA-15, which are the most important members of mesoporous materials, were synthesized and surface modified by grafting method. 3- (Aminopropyl) –triethoxysilane (APTES), 3-(aminopropyl)-trimethoxysilane (APTMS) and Bortriisopropoxide [B(OiPr)3] were used for modification. Synthesized and surface modified MSNs were characterized by Fourier Transform Infrared Spectroscopy (FTIR), Nuclear Magnetic Resonance Spectroscopy (NMR), Small Angular X-Ray Scattering (SAXS), High Resolution Transparent Electron Microscopy (HRTEM), N2 adsorption-desorption (BET) isotherms and elemental analysis techniques. Ampicillin was chosen as the model drug for the examination of drug loading-release capacity of bare and modified MCM-41 and SBA15. Ampicillin is an amino penicillin beta-lactam antibiotic used in the treatment of bacterial infections that usually caused by organisms such as gram-positive bacteria. Quantities of ampicillin both loaded to bare and modified MSNs and released in simulated body fluid were determined by fallowing Liquid Chromatography-Mass Spectrometry (LC-MS/MS). It was determined that surface modification of MCM-41 and SBA-15 enhanced the ampicillin loading capacity, prevented the sharp concentration peak (peak-valley) formation in ampicillin release and the releasing was stable for 72 hours.