Comparison of the effects of CRAB and SLIM criteria on prognosis with ISS and R-ISS in multiple myeloma

Objective: Multiple Myeloma (MM) has become a disease with increasing survival with new treatment options, recurrence rates are still very high. This study aimed to examine the effects of the presence and number of CRAB or SLiM at the time of diagnosis on disease-free survival (PFS) and overall survival (OS) in comparison to ISS and R-ISS and to contribute to the literature. Materials and Methods: The data of 208 patients diagnosed with MM were retrospectively reviewed. The presence and number of CRAB and SLiM factors, ISS, R-ISS at the time of diagnosis, and their effects on OS and PFS were examined. Results: According to univariate analysis results, age, MM subtype, anemia, hypercalcemia and ASCT were found to be effective on overall survival. In contrast, the effect of ISS and R-ISS on OS and PFS could not be demonstrated. OS was found to be statistically significant according to the number of CRAB (p=0.035). Although a decrease in the ortanca OS value was observed as the number of SLiM factors increased, it was not found to be statistically significant (p=0.429), but a significant decrease in the ortanca PFS value was observed and found to be statistically significant (p=0.049). Conclusion: It was observed that as the number of CRAB or SLiM increased, the rate of patients having advanced ISS and R-ISS increased. Our study is based on real-life data and emphasizes that the presence and number of CRAB and SLiM are practical prognostic indicators that can replace ISS and R-ISS. Key Words: CRAB, multiple myeloma, SLiM, stage, survival