A retrospective assesment: Effect of presence of oiligoclonal band on prognosis in ms patients

Multiple Sclerosis (MS) is one of the most cause of neurologic disability in young adults. Immunoglobulin G ( ıgG/ Oligoclonal band) which detect in cerebrospinal fluid, is important biomarker, commonly used for diagnosis. The effects of positive of OCB on prognosis in MS patients are still researched. The aim of this study was to investigate the relationship between the frequency of OCB in CSF, and the effect of the presence of oligoclonal band on disability degree and prognosis. Patients who had cerebrospinal fluid analysis and diagnoised with relapsing –remitting multiple sclerosis and clinical isolated syndrome in our centre, were included to study. Patients were separated into two groups as OCB -negative group and OCB -positive group; and demographic data, baseline clinical features, radiological features on MRI, disability ratings and disease activities at the 5th and final years of follow-up were compared between these two groups. The presence of contrast enhancing lesions in basal MRIs in the OCB negative group was found to be statistically significant compared to the OCB positive group. There was no statistically significant difference with regard to other parameters. Although OCB negativity seems to be adverse prognostic factor in our study, there are a numerous studies whose results was found unrelated. One of the most important reason might be involvement of different T-cell and B-cell-mediated immunopathogenetic processes in disease pathogenesis. Different designs, patient populations and number of patients in studies also might cause different results.