Investigation of immune activation and inhibition parameters in patients with psoriasis vulgaris

Psoriasis is a chronic inflammatory skin disease characterized by raised, red scaly plaques. Although this disease is more common in American, Canadian, and European populations, it affects approximately 2-3% of the population worldwide. Psoriasis is also associated with a combination of various diseases, suggesting that the underlying pathogenesis of the disease is greater than "skin". It may worsen gradually with age, its severity may increase or decrease. The severity of the disease depends on inheritance and environmental factors. Psoriasis patients have significant psycho-social disability and have a major impact on patients' quality of life. It is costly to both patients and healthcare systems. The subject of this thesis study is to investigate whether there is a correlation with the disease between serum levels of IgE, IgM, IgA and IgG associated with psoriasis vulgaris and total T lymphocyte, CD4 and CD8, which are mentioned in the literature and some studies have been conducted. In the studies, the levels of immunoglobulins were measured with Roche devices. Total T lymphocyte, CD4 and CD8 cells were measured by BD FacsCalibur brand flow cytometry. Serum IgE, IgG, IgM and IgA levels were found to be higher in patients with psoriasis vulgaris compared to healthy controls and were statistically significant (p <0.05). Total T lymphocyte and CD8 percentages were found to be significantly higher in patients with psoriasis vulgaris compared to healthy controls (p <0.05). However, the results of CD4 cells were not significant. This situation is compatible with previous studies. For more detailed data, the patient and control group can be expanded.