Searching the antioxidative and antiinflammatory effects of sanggenon C on acetaminophen intoxication in rats

In this study, the antioxidant and anti-inflammatory capacity of Sanggenon C against acute toxicity caused by Acetaminophen in rats and its effects on tissues were investigated. Four groups were formed from Sprague-Dawley male rats. No procedure was applied to the rats in the control group (Group 1). Acetaminophen 0,5 g / kg was administered intraperitoneally to rats in the acetaminophen group (Group 2). Sanggenon C was administered to rats in Sanggenon C group (Group 3) 0.1 mg / kg intravenously. The rats in the Therapeutic Group (Group 4) were administered 0,5 g / kg acetaminophen and then 0.1 mg / kg Sanggenon C 4 hours later. In blood and tissue samples taken from rats; AST, ALT, ALP, LDH, CK, MDA, GSH, NO, TAS, TOS, IFN-g, IL-1β, IL-6, TNF-α, NF-KB, PGE2, COX-2 measurements and tissue histopathological analyzes were performed. Obtained results have been shown that acetaminophen induces oxidative stress and inflammation. It was observed that Sanggenon C administration increased the antioxidant capacity and had positive effects on inflammation in this toxication caused by Acetaminophen. Sanggenon C Group and Therapeutic Group datas have been found remarkable in terms of the effects of this flavonoid and its place in the literature.