Ratlarda diklofenak sodyum maruziyetinin kalp dokusu üzerindeki etkilerine karşı gum arabic'in muhtemel koruyucu rolü

Diclofenac sodium (DS) is a non-steroidal anti-inflammatory drug most widely prescribed. DS acts as an antipyretic, analgesic, anti-inflammatory, and anti-coagulant. It causes serious cardiovascular events. Gum Arabic (GA) is an exudate of the Acacia Senegal tree. GA has positive treatments for several degenerative diseases. The aim of this study is to investigate the effect of GA on the healing of heart tissue damage caused by DS exposure in rat model using stereological techniques. 40 Wistar albino male rats were divided into four groups as follows: The Control group (n=10) was assigned as a control group. However, this group received no treatment. DS group (n=10); was treated by DS with a dose of 3.6 mg/kg/day orally for 15 days. GA group (n=10); was treated by GA only with a dose of 7.5 g/kg/day orally by oral gavage for 15 days. GA+DS group (n=10); was treated by DS and GA with a dose of 3.6 mg/kg/day, 7.5 g/kg/day respectively, orally for 15 days. In this study, possible healing effects of GA against the degenerative effect of DS were examined by histological and stereological methods. The physical dissector methods were performed to investigate the difference in counts of the cardiomyocytes of the left ventricles of each animal among all groups. The study found that DS has no harmful effects on the left ventricles' structure and function when administered by oral gavage. Biochemical investigations showed no change in antioxidant levels between the groups. There is no significant difference between groups in terms of cardiomyocyte counting. However, our qualitative analysis showed a toxic effect of DS on the heart tissue cells. It can be concluded that despite some minor changes that were observed between the groups, they have not reached statistical levels, and they likely tend to be due to the toxic effects of DS. Regarding the beneficial effect of GA, we can conclude that there are no significant differences between the groups. Keywords: Gum Arabic, Diclofenac, NSAID, Heart tissue, Stereology